Published:  2019-12-30

The impact of depression and anxiety treatment on biological aging and metabolic stress: study protocol of the Mood treatment with antidepressants or running (MOTAR) study

Authors:  Bianca A. Lever-van Milligen, Josine E. Verhoeven, Lianne Schmaal, Laura S. van Velzen, Dóra Révész, Catherine N. Black, Laura K. M. Han, Melany Horsfall, Neeltje M. Batelaan, Anton J. L. M. van Balkom, Digna J. F. van Schaik, Patricia van Oppen, Brenda W. J. H. Penninx

Tags:  Aging, Antidepressant, Anxiety, Cortisol, Depression, Inflammation, Metabolic syndrome, Running therapy, SSRI, Telomerase activity, Telomere length, Treatment, fMRI

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Depressive and anxiety disorders have shown to be associated to premature or advanced biological aging and consequently to adversely impact somatic health. Treatments with antidepressant medication or running therapy are both found to be effective for many but not all patients with mood and anxiety disorders. These interventions may, however, work through different pathophysiological mechanisms and could differ in their impact on biological aging and somatic health. This study protocol describes the design of an unique intervention study that examines whether both treatments are similarly effective in reducing or reversing biological aging (primary outcome), psychiatric status, metabolic stress and neurobiological indicators (secondary outcomes).