Published:  2013-06-01

Effects of induced hyperinsulinaemia with and without hyperglycaemia on measures of cardiac vagal control

Authors:  M. Berkelaar, E. M. W. Eekhoff, A. M. C. Simonis-Bik, D. I. Boomsma, M. Diamant, R. G. Ijzerman, J. M. Dekker, L. M. ’t Hart, E. J. C. de Geus

Tags:  Autonomic nervous system, GLP-1, Heart rate variability, Insulin, Parasympathetic activity

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We examined the effects of serum insulin levels on vagal control over the heart and tested the hypothesis that higher fasting insulin levels are associated with lower vagal control. We also examined whether experimentally induced increases in insulin by beta cell secretagogues, including glucagon-like peptide-1 (GLP-1), will decrease vagal control.